Multi-objective optimization identifies a specific and interpretable COVID-19 host response signatureArticle Published on 2022-12-212023-07-11 Journal: Cell Systems [Category] COVID19(2023년), [키워드] COVID-19 cross-reactivity epigenomics host response signature interpretability optimization plasmablasts robustness transcriptomics viral infection diagnosis. [DOI] 10.1016/j.cels.2022.11.008 PMC 바로가기
Sex-biased expression of the TLR7 gene in severe COVID-19 patients: Insights from transcriptomics and epigenomicsArticle Published on 2022-12-012022-11-16 Journal: Environmental research [Category] 유전자 메커니즘, [키워드] acute phase analyzed Blood Cohort coronavirus disease COVID-19 COVID-19 patient CpG DNA DNA methylation dose downregulated embryogenesis epidemiological data epigenomic epigenomics Evidence expression female females gene product Genetic variation Genome-wide association studies Host inactivation incidence incidence of COVID-19 independent insight long-COVID-19 male males Methylation n-Counter. nasal patients Post-infection RNAseq Saliva Severe case severe COVID-19 severity Sex significantly higher stratified suggested timepoint TLR7 TLR7 gene transcriptomics with COVID-19 [DOI] 10.1016/j.envres.2022.114288 PMC 바로가기
Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies Research Published on 2022-06-072022-10-05 Journal: Nature Communications [Category] 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] approach association competing Computational drug conformation ENhance epigenomic epigenomics eQTL expression expressions extension gene expression level genomic help increase independent Informed loci median Model outperform predict prediction Quantitative Region target gene traits transcriptome-wide variants [DOI] 10.1038/s41467-022-30956-7 [Article Type] Research
Differentially expressed plasmatic microRNAs in Brazilian patients with Coronavirus disease 2019 (COVID-19): preliminary resultsOriginal Article Published on 2022-03-172023-06-15 Journal: Molecular biology reports [Category] COVID19(2023년), MERS, SARS, [키워드] Biomarkers COVID-19 epigenomics MicroRNAs SARS-CoV-2 [DOI] 10.1007/s11033-022-07338-9 PMC 바로가기 [Article Type] Original Article
Placental methylome reveals a 22q13.33 brain regulatory gene locus associated with autismResearch Published on 2022-02-162023-08-30 Journal: Genome Biology [Category] E형 간염, [키워드] Autism Spectrum Disorder DNA methylation epigenomics Human genetics hypoxia neurodevelopment Placenta Postmortem brain Prospective Study structural variants [DOI] 10.1186/s13059-022-02613-1 PMC 바로가기 [Article Type] Research
Epigenomic and transcriptomic analyses reveal differences between low-grade inflammation and severe exhaustion in LPS-challenged murine monocytesArticle Published on 2022-01-282022-10-04 Journal: Communications Biology [Category] 바이오마커, [키워드] analysis analyzed bacterial endotoxin Characteristics Chronic diseases chronic inflammation condition contribute COVID-19 driving Epigenetic epigenomic epigenomics evaluate expression Gene Expression Genes High dose High-dose immune induce Inflammation interferon response low dose low-dose low-grade inflammation LPS marrow-derived macrophage memory Modification monocyte murine occur Pathogenesis pathogenic pathway Pathways PBS proliferative Regulation responses Sepsis Signaling target the cell therapeutic TLR4 transcriptomic underlie upregulate while [DOI] 10.1038/s42003-022-03035-2 PMC 바로가기 [Article Type] Article
Role of miRNAs as biomarkers of COVID-19: a scoping review of the status and future directions for research in this fieldCovid-19의 바이오 마커로서 miRNA의 역할 :이 분야의 연구를위한 상태와 향후 방향에 대한 범위 검토Review Published on 2021-11-172022-09-01 Journal: Biomarkers in Medicine [Category] MERS, 바이오마커, 진단, [키워드] animals Biomarker Biomarkers cardiovascular dysfunction carried Cell COVID-19 database described diagnosing Diseases dysregulated epigenomics identify immune response in viral independent infected cells material miR-126 miR-155 miRNA miRNAs nine patients with COVID-19 Potential biomarker potential biomarkers proliferation provide Replication Research resolved review role SARS-CoV-2 selected severity of COVID-19 suggested Viral viral replication [DOI] 10.2217/bmm-2021-0348 PMC 바로가기 [Article Type] Review
Comprehensive mapping of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions생체 내 SARS-CoV-2 상호 작용의 포괄적 인 매핑은 기능적 바이러스-숙주 상호 작용을 나타냅니다Article Published on 2021-08-252022-09-10 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] approach bind Cell cells cellular Comprehensive element epigenomics functional Genome global health Health Host host mRNA identify Illumina in viral in vivo Interaction interactions Methylation mitochondrial molecular mutant observé pathogenicity platform regions report reveal RNA RNA sequencing RNA-RNA interaction RNA-RNA interactions RNAs SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 viral secondary structure Sequencing small nucleolar RNA structures subgenomic RNA subgenomic RNAs targeted therapy the SARS-CoV-2 genome untranslated regions Viral viral genome virus virus genome virus infection Virus-host interaction Virus-host interactions wildtype Δ382 [DOI] 10.1038/s41467-021-25357-1 PMC 바로가기 [Article Type] Article
Epigenomics in COVID-19; the link between DNA methylation, histone modifications and SARS-CoV-2 infectionCOVID-19의 후성유전학; DNA 메틸화, 히스톤 변형 및 SARS-CoV-2 감염 사이의 연결Editorial Published on 2021-04-202022-09-11 Journal: Epigenomics [Category] MERS, SARS, 유전자 메커니즘, [키워드] COVID-19 DNAm epigenetic mechanisms epigenomics histone modifications Modification SARS-CoV-2 SARS-COV-2 infection [DOI] 10.2217/epi-2021-0057 PMC 바로가기 [Article Type] Editorial
Functional annotations of three domestic animal genomes provide vital resources for comparative and agricultural researchArticle Published on 2021-03-232022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] Agricultural genetics animal annotation Community Comparative analysis complex conserved Critical dataset DNA driver eight element epigenomics functional Gene regulation genetics Genome genomes independent information non-coding variants phenotypic predicted regulatory element Research resource resources target gene tissue traits transcription factor unique Variation [DOI] 10.1038/s41467-021-22100-8 PMC 바로가기 [Article Type] Article